Mittwoch, 8. März 2017

Paar aktuelle Dinge in Bezug auf Hufrehe und Heparin

Der Link ist leider auf Englisch

Eine deutschsprachige aktuelle Studie über die Wirkungsweise von Heparin bei Hufrehe kann ich leider nicht finden.

Ich kopiere mal die wichtige Textpassage da raus.

In regard to the use of heparin, there are controversial results. MARTINS FILHO et al. (2008) found no reduction in hoof injuries with heparin treatment in the start of lameness, when laminitis was induced for carbohydrate administration. However, the substance prevented laminitis in horses with proximal duodenum jejunitis (LA REBIERE et al., 2008). Additionally to the antithrombotic effect of heparin, it is suggested that the substance contain anti-inflammatory effects.
 DE LA REBIERE G. , et al. Effects of unfractionated and fractionated heparins on myeloperoxidase activity and interactions with endothelial cells: possible effects on the pathophysiology of equine laminitis. Veterinary Journal, v.178, p.62-69, 2008.Available from: <Available from: >. Accessed: Sept. 05, 2014. doi: 10.1016/j.tvjl.2007.08.033. [ Links ]


As heparins are sometimes used to prevent equine laminitis, the interactions between equine neutrophil myeloperoxidase (MPO), unfractionated (UFH) and fractionated low molecular weight (LMWH) heparins and digital endothelium have been investigated. The effects of the heparins on purified equine MPO activity were tested by immunocapture followed by enzymatic detection. Endothelium–MPO interactions were assessed by measuring total and active MPO uptake by arterial and venous digital endothelial cells in culture with or without the addition of heparins. A dose-dependent MPO inhibition by UFH and LMWH was seen, with the greatest reduction in MPO activity noted with the highest concentration of LMWH. The MPO capture was greater in arterial cells, but heparins better inhibited MPO capture in venous cells. The activity of cell-bound MPO was almost completely suppressed by the heparins, and no differences were observed between UFH and LMWH. The results confirm the anti-inflammatory properties of heparins and allow a better understanding of the potential role of MPO in laminitis.


  • Myeloperoxidase;
  • Heparin;
  • Endothelial cell culture;
  • Equine laminitis;
  • Inflammation
  • Also sollte ich mal rausfinden , was denn genau
    Myeloperoxidase ist, denn die wurde durch Heparin im Zusammenhang mit Hufrehe gehemmt.

  • LG Renate

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